Brave Trisha Roberts, 26, dedicated her working life to helping sick patients but her mental health took a "downward spiral" as she battled a degenerative back problem.
She had been admitted to hospital two weeks before her death where doctors told here there was "nothing they could do" for her spinal condition.
An inquest today heard Trisha, from Bangor in North Wales, was due to marry her partner Paul Jones but had to cancel multiple weddings due to the pandemic.
Healthcare worker Paul said: "This led to a downward spiral of her mental health.
"We had multiple weddings cancelled. She saw no future for herself."
The relationship broke down the day before her death and Trisha was tragically found dead in bed on February 24.
The inquest in the Black Country Coroner's Court heard Trisha was born in Bangor, North Wales, and worked at the nearby Ysbyty Gwynedd hospital.
She later got a role working on the trauma and orthopaedics wards at New Cross Hospital in Wolverhampton.
The inquest heard the dedicated nurse had been living with partner Paul's parents before her death.
The medical cause of death was given as drug toxicity.
Senior coroner Joanne Lees said there was a "clear intention by Trisha to end her life."
Mrs Lees recorded a conclusion of suicide.
After Trisha's death, sister Tammy Lou paid tribute to the "bubbly, energetic, enthusiastic" nurse.
She said: "She was loved very much by all and was a very determined and hard worker. She would always be there to help in any way she could.
"Trisha would go above and beyond to help and be there in your hour of need. She was and always will be our hero.
"A hero not only to her family but to the NHS. The gaping hole she has left in our hearts, minds and in lives will never be filled.
"She often told us with tear-filled eyes that she held the hands of these who unfortunately succumbed to the Covid virus and was often the last person they saw."